Laser vein removal is safe and minimally invasive, but as with any medical treatment there are potential side effects and risks. Common side effects of the treatment include: temporary redness, swelling, or bruising, skin sensitivity for a short period of time, temporary changes in skin color, and nerve irritation (temporary numbness or tingling near the treatment area). More severe, but uncommon risks are blistering or minor burns, vein inflammation, and blood clots.